For People
Rest
Sleep and down-regulation — you don't grow in the gym, you grow here.
This is the most undervalued formula in the performance line and probably the most important. Growth hormone release, tissue repair, memory consolidation and the clearing of the day's metabolic load all happen in deep sleep. An athlete who trains perfectly and sleeps badly is running an incomplete program.
The problem for hard-training people is rarely tiredness. It is that the system will not switch off — a nervous system that has been driven all day does not simply stop when the lights go out, and the harder the block, the more true that becomes. This blend works on the switching off rather than on sedation.
Take it in the evening, and on rest days. It is composed from the classical shen-settling plants: the ones the old framework reaches for when the spirit is restless rather than when the body is merely awake.
What it supports in the body
The body systems the herbs in this formula are traditionally understood to nourish — resolved through our knowledge graph, where the classical record and modern biology are read together. Structure and function, never a claim of treatment.
Where measure & tradition agree
Systems this blend’s herbs are measured to engage in human binding data — and traditionally named for, independently. The number is how many herbs in the blend converge there. Two evidence systems arriving at the same place, separately, is our highest standard. See the research →
For People
Small-batch. Dual-extracted where it matters. Made by hand.
How to take it
1/4 tsp (up to 1 tsp) of extract powder in hot water, tea, coffee, a smoothie, or food, once daily. Begin with light doses — our extracts are very potent.
Whole plant, never isolated
Concentrated extracts of the whole botanical — the way the body recognizes it.
Cited to measured biology
Every action we describe traces to the compound and its measured target.
Structure & function
We describe what an herb nourishes — never a claim to treat disease.
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What you get
What this formula gives you
Supports the deep sleep where repair and adaptation actually happen
Works on down-regulation rather than sedation
Built from the classical shen-settling pairings of the tradition
Pairs with Recovery, which carries the same logic through the evening
How it works
The science of Rest
Not buzzwords — the actual biology of the plants in this formula: their compounds, the targets those compounds are measured to engage, and the systems they nourish.
Ziziphus jujuba is the classical sleep seed of the materia medica, carrying jujubosides A and B and their aglycone jujubogenin — the saponin chemistry behind suan zao ren, the reference formula ingredient for restless sleep in the Chinese tradition. Polygala tenuifolia, yuan zhi, is its traditional partner, with tenuifolin and tenuigenin; the pairing of these two is one of the oldest shen-settling combinations in the pharmacopoeia.
Ganoderma lucidum brings the ganoderic acids and its long association with the settled spirit — reishi is classified among the shen tonics, not merely the immune ones. Schisandra chinensis contributes the schisandrin lignans, the astringent quality that the tradition describes as holding the spirit in. Across the four, our data records two shared measured targets, ACHE and AKR1B1. Acetylcholinesterase is worth naming because cholinergic signaling is central to how the nervous system transitions between states — though the honest framing is that the convergence here is narrow, and the case for this blend rests on a long and specific traditional record rather than on breadth of measured overlap.
The molecules, measured
A formula is a community of compounds. Below are active molecules from the herbs in this blend and the proteins each is measured to engage — the precise points where the plants meet biology. So you see not just that it works, but how.
Ganoderma lucidum
Ganoderic acid A
PubChem ↗Measured to act on
An enzyme that locally regenerates active cortisol, shaping how tissues respond to the body's stress hormone.
An enzyme that quiets cortisol inside kidney and salt-handling tissues, helping govern fluid and mineral balance.
An enzyme that converts glucose into sorbitol, part of how cells handle sugar.
Ganoderic acid B
PubChem ↗Measured to act on
The enzyme that breaks down acetylcholine, resetting nerve and muscle signals between pulses.
A blood enzyme that breaks down acetylcholine and helps clear certain compounds from circulation.
An enzyme that converts glucose into sorbitol, part of how cells handle sugar.
Ziziphus jujuba
Betulinic acid
PubChem ↗Measured in the lab: binds tightly to Albumin · Kd 593 nM
Measured to act on
A receptor that senses bile acids and helps govern metabolism and energy balance.
An enzyme that dials down insulin and growth signaling by removing phosphate tags.
Rutin
PubChem ↗Measured in the lab: binds very tightly to Tyrosinase · IC50 0.856 nM
Measured to act on
An enzyme that cuts proteins at the cell surface, part of normal protein turnover.
The enzyme that switches off the nerve messenger acetylcholine after a signal.
A protein that helps organize DNA and acts as an alarm signal during tissue stress.
Polygala tenuifolia
3,4,5-Trimethoxycinnamic acid
PubChem ↗Measured in the lab: binds to 5-hydroxytryptamine receptor 2C · IC50 2.5 µM
Measured to act on
A serotonin receptor involved in mood, calm, and nervous-system signaling.
A serotonin receptor in the brain involved in mood, perception, and signaling.
A serotonin receptor that helps govern appetite, mood, and emotional balance.
Schisandra chinensis
Schisandrin B (Wuweizisu B)
PubChem ↗Measured in the lab: binds very tightly to Multidrug resistance-associated protein 1 · IC50 1.25 nM
Measured to act on
A guardian enzyme that senses DNA stress and helps coordinate repair.
A sentinel enzyme that detects DNA breaks and signals the cell to mend them.
An enzyme that helps stitch broken DNA strands back together.
Schisandrin C (= Wuweizisu C)
PubChem ↗Measured to act on
The enzyme that drives the body's inflammatory response.
The liver's busiest enzyme for breaking down compounds the body takes in.
A liver enzyme that helps metabolize and clear many compounds from the body.
Cited science · not claims
Everything we publish about these plants traces to a primary source — the compounds to PubChem, ChEMBL, and BindingDB, the traditional uses to named, dated herbals. We describe what a plant is and what it is understood to nourish — the body’s own systems, structure and function only. We do not claim it treats, cures, or prevents any disease, and nothing here is a substitute for professional care. See our method & sources →
These statements have not been evaluated by the Food and Drug Administration. Not intended to diagnose, treat, cure, or prevent any disease.
Why these herbs together
The shared mechanism
A formula is not a pile of herbs — it is herbs whose actions meet. Below are the molecular targets that more than one plant in this blend is measured to engage. Where they converge is the blend's reason to exist.
Reishi · Jujube
Reishi · Jujube
Each convergence is a gene whose protein two or more of this formula’s herbs are measured to engage (PubChem BioAssay & ChEMBL). It describes characterized molecular activity and the protein’s normal role — structure and function only, never a claim to treat, cure, or prevent any disease.
In practice
Who it’s for, and how to use it
Who it’s for
For the hard-training person whose system will not switch off — anyone who is tired but wired at the end of a block, and anyone who has realized that their sleep, not their program, is the ceiling.
How to use it
1/4 tsp (up to 1 tsp) in hot water, tea, or food, in the evening and on off days. Begin with light doses — our extracts are very potent.
Measure · 1/4 tsp (up to 1 tsp) of extract powder in hot water, tea, coffee, a smoothie, or food, once daily. Begin with light doses — our extracts are very potent.
What’s inside
Reishi, Jujube, Polygala and Schizandra — whole-plant extracts in equal parts, the mushroom dual-extracted.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Introduce one formula at a time and notice how the body responds; if you are pregnant, nursing, or on a prescription, know the interaction before you begin.
Pairs well with
Formulas that share Rest's botanicals
Built from overlapping herbs, these reinforce Rest along the same lines — the shared-botanical kinship our genome engine maps.