Herbs/Schizandra

berry

Schizandra

Schisandra chinensis

Also known as

五味子チョウセンゴミシ chōsen-gomishi오미자 omijaЛимонник limonnik

Suitable For

Peoplenatural energy, stamina, and endurance — plus gentle liver and cleansing support
PetsUse with care · Adaptogen berry traditionally used to support a healthy stress response, liver/antioxidant function, and steady energy.
Plantsflowering, fruiting, and finish as a dilute bloom-stage tonic

Schisandra chinensis — the rare 'five-flavor berry,' rich in lignans that support liver function, mental performance, and stress resilience. One of the few botanicals to engage all five taste profiles at once.

What it nourishes in the body

LiverDigestiveMusculoskeletalNervousMetabolic

The body systems this herb is traditionally understood to support — resolved through our knowledge graph, where the classical record and modern biology are read together. Structure and function, never a claim of treatment.

Where measure and tradition agree

Liver & Detox

Schizandra is measured to engage this system in human binding data — and the recorded tradition named it for it independently. Two evidence systems arriving at the same place, separately, is our highest standard. See the research →

Categoryberry
Part Usedfruit (berry)
Extraction10:1 extract
Flavorsour
OriginNorthern China, Russian Far East
adaptogenliverenergystressaromatic

10:1 Concentrated Extract

$20/ 1 oz / 12 g

Whole-plant. Small-batch. Potent.

How to take it

1/4 tsp (up to 1 tsp) in hot water, tea, coffee, a smoothie, or food, once daily — begin with light doses; our extracts are very potent.

Whole plant, never isolated

Concentrated extracts of the whole botanical — the way the body recognizes it.

Cited to measured biology

Every action we describe traces to the compound and its measured target.

Structure & function

We describe what an herb nourishes — never a claim to treat disease.

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The Botanical

Schizandra, in depth

Character

Schizandra (Schisandra chinensis) is the celebrated wu wei zi — the "five-flavor berry" — a small, glossy crimson fruit borne on a woody climbing vine native to the cold northern forests of China and the Russian Far East. Its name is its signature: alone among botanicals, a single berry carries all five classical flavors at once — sour and sweet in the flesh, pungent and bitter in the seed, salty in the whole — and it is this rare completeness that earned it a place at the very top of the herbal hierarchy. In the lineage we carry, Schizandra is not a casual tonic but a superior, daily-use botanical: the kind of plant traditionally reserved for sustained vitality rather than fleeting effect, taken to build a deep, steady reserve of energy over time. As an adaptogen berry, it is prized for nourishing the body's own capacity to meet demand with poise — to draw on stamina without burning hot, to stay clear and grounded under load.

Our Schizandra is a potent 10:1 fruit extract, concentrated from the whole berry so that the full five-flavor spectrum and the lignan-rich character of the seed are carried into a few quiet grains of powder. It belongs to the rare class of plants the tradition trusts for the long arc — a botanical you live alongside, building resilience season after season, rather than reaching for in a moment of crisis.

In the Body

Schizandra is most closely associated with the liver — the body's great filtering and metabolic seat — and with the systems of energy, stamina, and stress resilience that radiate from a well-toned internal economy. Its defining constituents are the dibenzocyclooctadiene lignans (the schisandrins and gomisins), a structurally distinctive class of compounds concentrated in the seed, which the tradition has long understood as the source of the berry's tonifying character. These lignans speak to the liver's own filtering and clearing systems — the body's innate capacity to recognize, transform, and carry off what it no longer needs — supporting the organ's natural housekeeping rhythm and its capacity to tone and renew its own tissue. This is structure and function in the truest sense: not an intervention against the liver, but nourishment of the work the liver already knows how to do.

Beyond the lignans, the berry carries organic fruit acids (its pronounced sourness), aromatic mono- and sesquiterpenes from the volatile oils, and fruit polysaccharides — a whole-spectrum matrix that supports the body's antioxidant defenses and its healthy response to oxidative and metabolic load. As an adaptogen, Schizandra's gift is to the body's stress-response architecture: it supports the steady, even functioning of the systems that govern endurance, mental clarity, and recovery, helping the body meet exertion with stamina and return to calm without the spike-and-crash of a stimulant. The five flavors are not folklore but a map of breadth — sour to gather and tone, sweet to nourish, pungent and bitter to move and clear, salty to ground — a single fruit engaging multiple systems at once. The result is a botanical that supports vitality, focus, and a resilient, grounded baseline of energy.

The Tradition

Schizandra holds an exalted place in classical East Asian herbalism, where it is recorded as wu wei zi, the "five-flavor seed," and counted among the superior tonic botanicals — those traditionally taken over long stretches to build reserve and sustain vitality rather than to address a passing complaint. The herbals describe it as astringing and gathering, a fruit used to consolidate the body's energy, to steady the spirit and the senses, and to support the liver and the body's natural cleansing rhythm. Its five-flavor completeness was understood to let a single berry reach the body's several internal systems at once, which is why it was so prized by scholars and laborers alike for endurance, clarity, and steadiness under sustained demand. GGG NATURAL carries Schizandra in this lineage — a research-grade extract of a fruit that thousands of years of recorded human practice have placed among the most trusted tonics of the herbal tradition.

The berry

Schizandra,
as it actually grows.

Schisandra chinensis earns its Chinese name wu wei zi — "five-flavor fruit" — because a single berry simultaneously delivers sweet, sour, salty, bitter, and pungent notes on the palate. The dried berries have been steeped as a restorative tonic tea across Northeast Asian traditions for centuries, prized as much for their complexity of flavor as for their place in daily ritual.

How to Use

Across the Three Kingdoms

One herb, prepared once, serving people, pets, and plants from a single botanical practice — each with its own measure and care.

People

Benefit

natural energy, stamina, and endurance — plus gentle liver and cleansing support

How to Use

1/4 tsp (up to 1 tsp) in hot water, tea, coffee, a smoothie, or food, once daily — begin with light doses; our extracts are very potent.

Pets

Dogs & companion animals

Benefit

Adaptogen berry traditionally used to support a healthy stress response, liver/antioxidant function, and steady energy.

How to Use

Dilute hot-water extract or powder; give a small pinch stirred into food, scaled to body weight (start with a fraction of the human-equivalent amount for a small pet and build up slowly). Tonic use a few days per week, not a continuous high dose.

By Animal

Cats

EFSA: safe in feed ≤47 mg/kg, but Schisandra lignans actively inhibit UGT/CYP — the glucuronidation pathway cats already lack — and the fruit carries volatile mono/sesquiterpenes; keep the dose minimal and infrequent.

Dogs

EFSA FEEDAP concluded the fruit tincture safe in dog feed up to 56 mg/kg; well tolerated as a dilute tonic for a healthy dog.

Horses

EFSA concluded safe in horse feed up to 47 mg/kg; hindgut-friendly as a dilute tonic. (Competition restriction is regulatory, see competition field.)

Birds

EFSA explicitly assessed poultry and concluded the tincture safe (~12–18 mg/kg feed); dilute tonic doses are well within range. Lower per-kg level reflects feed-intake math, not a toxicity signal.

⚑ Sport horses: FEI/USEF: Schisandra is a calming/energizing adaptogen, and the FEI expressly forbids any herbal product used to alter a horse's demeanor (calming or stimulant) plus warns against tonics of unknown composition. Treat as a prohibited/controlled-substance risk under FEI EADCM and USEF GR4 — do not give to a horse in or near competition without clearance.

Safety

EFSA's FEEDAP panel (2024) assessed an omicha tincture from S. chinensis fruit and concluded it is SAFE as a feed additive for dogs (≤56 mg/kg feed), cats and horses (≤47 mg/kg feed), and poultry (~12–18 mg/kg feed) — so a dilute tonic in moderate use is well within safe bounds for healthy animals. Start low and scale to body weight. Conditional caveats (do NOT apply to a healthy animal in normal use): Schisandra lignans inhibit CYP450 and UGT (glucuronosyltransferase) enzymes, so it can raise blood levels of co-administered drugs — use caution and consult a vet for any animal on medication, especially narrow-therapeutic-index drugs. Its mild liver-stimulating action means caution with pre-existing liver or gallbladder disease. Avoid in pregnancy/lactation (traditionally uterine-stimulating; not studied in pregnant animals). As an adaptogen it may have subtle CNS/energy effects, so discontinue before sedation/surgery and consult a vet. EFSA flags the raw tincture as a skin/eye irritant and dermal/respiratory sensitizer for HANDLERS (not a consumed-product risk) — handle concentrated powder with care. Source any product from a reputable supplier with verified species identity and no contaminants.

Source: EFSA FEEDAP Scientific Opinion on omicha tincture from Schisandra chinensis for poultry, horses, dogs and cats, EFSA Journal 2024 (doi:10.2903/j.efsa.2024.8731; PMC11004902); Schisandra lignan CYP450/UGT inhibition (PMC8000448); ASPCA Animal Poison Control (no S. chinensis toxicity entry); FEI Clean Sport Prohibited List (inside.fei.org); USEF GR4 Drugs & Medications.

Plants

Garden, soil & foliage

Benefit

flowering, fruiting, and finish as a dilute bloom-stage tonic

How to Use

Dilute 1/8 to 1/4 teaspoon per gallon of water. Foliar feed at the lighter rate, or soil drench at the fuller rate, about once a month or every other feeding. Best worked in from pre-flower through bloom, as the plant sets and fills flower and fruit.

Best for

Flower & bloom

Safety

A dilute extract in the GGG Plants line; always dilute and start light.

Source: GGG Plants line formulation

Structure-and-function guidance for nutrition and vitality. Not intended to diagnose, treat, cure, or prevent any disease. Introduce one botanical at a time and notice how the body responds. Some plants interact with medication; if you are pregnant, nursing, or on a prescription, know the interaction before you begin.

What's inside

Schizandra,
down to the molecule.

The signature compound of Schizandra, rendered from its real structure in bronze and glass — the precise thing the plant carries, given the dignity it has earned.

The evidence chain

From the plant to the molecule to the body — traced.

Not a claim — a chain. Every link below traces to a primary record. This is what Schizandra is, measured.

1

The plant

Schizandra

2

carries the compound

Schisandrin B (Wuweizisu B)

PubChem
3

measured to engage

Multidrug resistance-associated protein 1 · IC50 1.25nM

BindingDB

which governs

A cellular pump that moves compounds out of cells.

4

serving the system

Liver · Digestive

5

and the tradition independently agrees — measured binding

The recorded herbal lineage names Schizandra a liver & detox herb. Independently, its compounds are measured to bind proteins of that system. Tradition and molecule, arrived at separately, converge— the strongest evidence we hold.

Structure and function only. The chain describes the plant’s characterized chemistry and traditional use — not a claim to treat, cure, or prevent any disease.

How it works

How Schizandra works in the body

A herb is never one thing — it is a community of compounds, each meeting the body in its own way. These are the active molecules in Schizandra and the proteins each one is measured to engage: the precise points where the plant meets your biology. So you see not just that it works, but how.

Schisandrin B (Wuweizisu B) molecule
Schisandrin B (Wuweizisu B) · real structure, PubChem CID 108130

Schisandrin B (Wuweizisu B)

PubChem ↗

Measured to act on

Serine/threonine-protein kinase ATR

A guardian enzyme that senses DNA stress and helps coordinate repair.

structure resolved ↗

Serine-protein kinase ATM

A sentinel enzyme that detects DNA breaks and signals the cell to mend them.

DNA-dependent protein kinase catalytic subunit

An enzyme that helps stitch broken DNA strands back together.

Multidrug resistance-associated protein 1

A cellular pump that ushers waste and foreign compounds out of cells.

structure resolved ↗

Menin/Histone-lysine N-methyltransferase MLL complex

A protein partnership that helps switch genes on by marking the DNA's packaging.

structure resolved ↗

Measured in the lab

Real measurements from binding studies. A tighter fit means the compound meets its target more readily — the figure in grey is the actual measured value.

Binds very tightly to Multidrug resistance-associated protein 1 · IC50 1.25 nM

Binds to Serine/threonine-protein kinase ATR · IC50 7.2 µM

Schisandrin C (= Wuweizisu C)

PubChem ↗

Measured to act on

Prostaglandin G/H synthase 2

The enzyme that drives the body's inflammatory response.

structure resolved ↗

Cytochrome P450 3A4

The liver's busiest enzyme for breaking down compounds the body takes in.

Concentrated in liverstructure resolved ↗

Cytochrome P450 3A5

A liver enzyme that helps metabolize and clear many compounds from the body.

Concentrated in liver, intestinestructure resolved ↗

Schisandrin A (= Deoxyschizandrin / Wuweizisu A)

PubChem ↗

Measured to act on

Prostaglandin G/H synthase 2

The enzyme that drives the body's inflammatory response.

structure resolved ↗

Multidrug resistance-associated protein 1

A cellular pump that ushers waste and foreign compounds out of cells.

structure resolved ↗

NAD-dependent protein deacetylase sirtuin-1

An enzyme tied to cellular energy, repair, and the body's response to fasting.

structure resolved ↗

Acetylcholinesterase

The enzyme that clears acetylcholine, a key messenger for nerves and muscles.

Concentrated in skeletal muscle, brain, tonguestructure resolved ↗

Glucagon-like peptide 1 receptor

A receptor involved in blood-sugar balance and the feeling of fullness after eating.

Concentrated in pancreas, heart musclestructure resolved ↗

Serine-protein kinase ATM

A sentinel enzyme that detects DNA breaks and signals the cell to repair them.

Cytochrome P450 3A4

The liver's busiest enzyme for breaking down compounds the body takes in.

Concentrated in liverstructure resolved ↗

Cytochrome P450 3A5

A liver enzyme that helps metabolize and clear many compounds from the body.

Concentrated in liver, intestinestructure resolved ↗

Tyrosyl-DNA phosphodiesterase 1

A repair enzyme that helps untangle and fix damaged DNA strands.

structure resolved ↗

Gomisin A (Schisandrol B-related / wuweizichun A)

PubChem ↗

Measured to act on

Prostaglandin G/H synthase 2

The enzyme that drives the body's inflammatory response.

structure resolved ↗

Prostaglandin G/H synthase 2

The enzyme that drives the body's inflammatory response.

Concentrated in urinary bladder, seminal vesicle, bone marrowstructure resolved ↗

Prostaglandin G/H synthase 1

An enzyme making prostaglandins that protect the stomach lining and aid clotting.

Concentrated in urinary bladder, skin 1, intestinestructure resolved ↗

Polyunsaturated fatty acid 5-lipoxygenase

An enzyme that turns fatty acids into messengers of the inflammatory response.

Concentrated in lymphoid tissue, lungstructure resolved ↗

Multidrug resistance-associated protein 1

A cellular pump that ushers waste and foreign compounds out of cells.

structure resolved ↗

Measured in the lab

Real measurements from binding studies. A tighter fit means the compound meets its target more readily — the figure in grey is the actual measured value.

Binds very tightly to Multidrug resistance-associated protein 1 · IC50 0.96 nM

Schisantherin A (Gomisin C / Schizantherin A, benzoyloxy lignan)

PubChem ↗

Measured to act on

Multidrug resistance-associated protein 1

A cellular pump that ushers waste and foreign compounds out of cells.

structure resolved ↗

Acetylcholinesterase

The enzyme that clears acetylcholine, a key messenger for nerves and muscles.

Concentrated in skeletal muscle, brain, tonguestructure resolved ↗

DNA-binding protein inhibitor ID-1

A regulatory protein that helps decide when cells grow versus mature.

structure resolved ↗

Measured in the lab

Real measurements from binding studies. A tighter fit means the compound meets its target more readily — the figure in grey is the actual measured value.

Binds tightly to Cytochrome P450 3A4 · Ki 399 nM

Schisanhenol (Gomisin K3, demethyl lignan)

PubChem ↗

Measured to act on

Tyrosyl-DNA phosphodiesterase 1

A repair enzyme that helps untangle and fix damaged DNA strands.

structure resolved ↗

Serine-protein kinase ATM

A sentinel enzyme that detects DNA breaks and signals the cell to repair them.

Histone acetyltransferase KAT2A

An enzyme that loosens DNA's packaging to help switch genes on.

structure resolved ↗

Glucagon-like peptide 1 receptor

A receptor involved in blood-sugar balance and the feeling of fullness after eating.

Concentrated in pancreas, heart musclestructure resolved ↗

Guanine nucleotide-binding protein G(s) subunit alpha

A relay protein that passes signals from cell-surface receptors to the inside.

structure resolved ↗

Ataxin-2

A protein involved in handling RNA and regulating cellular stress responses.

structure resolved ↗

Cited science · not claims

Everything we publish about these plants traces to a primary source — the compounds to PubChem, ChEMBL, and BindingDB, the traditional uses to named, dated herbals. We describe what a plant is and what it is understood to nourish — the body’s own systems, structure and function only. We do not claim it treats, cures, or prevents any disease, and nothing here is a substitute for professional care. See our method & sources →

These statements have not been evaluated by the Food and Drug Administration. Not intended to diagnose, treat, cure, or prevent any disease.

Works alongside

Other herbs that share Schizandra's terrain

Different plants reaching the same systems of the body — the convergence our genome engine maps. These nourish the terrain Schizandra supports:

Schizandra$20